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In cases of Guillain-Barré syndrome, what does the pathophysiology include?


A) Damage and loss of function in the motor neurons of the spinal cord and medulla
B) Encephalopathy, with disorientation, headache, and coma
C) Infection and inflammation of the motor cortex
D) Inflammation and demyelination of peripheral nerves, leading to ascending paralysis

E) A) and B)
F) A) and C)

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With regard to meningitis, choose the correct combination of microbe and the age group commonly affected.


A) E. coli: elderly
B) H. influenzae: neonate
C) N. meningitides: children and youth
D) S. pneumoniae: young children

E) B) and C)
F) A) and D)

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All of the following may precipitate a seizure EXCEPT:


A) hypoglycemia.
B) hypoventilation.
C) brain abscess.
D) high fever in young child.

E) A) and D)
F) A) and C)

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Common manifestations of rabies infection include:


A) headache, foaming at the mouth, and difficulty swallowing.
B) difficulty walking and coordinating movements.
C) decreased sensitivity to sound and touch.
D) vomiting, liver and kidney damage.

E) B) and C)
F) C) and D)

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Which of the following characteristics indicates that the CSF is normal?


A) Cloudy and pale yellow color
B) Presence of erythrocytes
C) Presence of numerous leukocytes
D) Clear and colorless fluid

E) None of the above
F) All of the above

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Which of the following impairments results from infection by the polio virus?


A) Pain and paresthesia in a cranial nerve or dermatome
B) Loss of motor and sensory function in the peripheral nerves
C) Inflammation and increased intracranial pressure
D) Loss of function of motor neurons of the spinal cord and medulla

E) All of the above
F) A) and D)

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Which of the following applies to Parkinson's disease?


A) Usually develops in men and women over 60 years of age.
B) There is no apparent genetic component.
C) The majority of cases are predisposed by intake of antipsychotic medications.
D) It rarely develops in women.

E) A) and B)
F) C) and D)

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In many types of encephalitis, such as St. Louis encephalitis, how are the viruses transmitted?


A) Carriers
B) Mosquito and tick bites
C) Respiratory droplet
D) Septic emboli in the circulation

E) All of the above
F) A) and D)

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What does the clonic stage of a seizure consist of?


A) A sudden strong skeletal muscle contraction and rigidity of trunk and limbs
B) A cry and contraction of abdominal and thoracic muscles
C) Alternating contractions and relaxation of skeletal muscles
D) Cessation of all skeletal muscle activity

E) B) and C)
F) C) and D)

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In the weeks following CVA, why might some neurological function return? 1) Presence of collateral circulation 2) Immediate therapy to dissolve thrombi and maintain perfusion 3) Reduced inflammation in the area 4) Development of alternative neuronal pathways


A) 1 only
B) 2 only
C) 1, 3
D) 2, 3, 4
E) 1, 2, 3, 4

F) A) and B)
G) A) and C)

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Which statement does NOT apply to the pathophysiology of multiple sclerosis?


A) Demyelination of axons
B) It affects the brain, spinal cord, and cranial nerves
C) It affects motor, sensory, and autonomic fibers
D) Progressive random degeneration of peripheral nerves

E) All of the above
F) None of the above

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Failure of the spinous processes to fuse, but without herniation of the meninges, is called:


A) spina bifida occulta.
B) meningocele.
C) myelomeningocele.
D) encephalocele.

E) C) and D)
F) A) and B)

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Which of the following are common early signs of multiple sclerosis?


A) Paralysis of the lower body, impaired cognitive function
B) Areas of numbness, weakness in the legs, visual problems
C) Sensory deficit in the legs and trunk, memory loss, urinary incontinence
D) Tremors, speech impairment, hearing loss

E) B) and C)
F) A) and B)

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Which of the following dietary supplements has reduced the incidence of spina bifida in recent years?


A) Vitamin B6
B) Folic acid
C) Vitamins A and D
D) Zinc and magnesium

E) A) and B)
F) A) and C)

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What is the probable source of an embolus causing a cerebrovascular accident (CVA) ?


A) Right ventricle of the heart
B) Femoral vein
C) Common carotid artery
D) Pulmonary artery

E) B) and D)
F) None of the above

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Collateral circulation is most likely to be present when a CVA results from:


A) rupture of a cerebral artery.
B) an embolus.
C) atherosclerosis.
D) vasospasm in the cerebral circulation.

E) All of the above
F) A) and B)

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Why are focal or generalized seizures sometimes an early indication of a brain tumor?


A) Surrounding inflammation stimulates neurons to discharge spontaneously.
B) Malignant tumors cause alkalosis, exciting the CNS.
C) Systemic effects of the brain tumor may cause seizures.
D) Metabolic effects of cancer change blood chemistry to trigger seizures.

E) B) and C)
F) B) and D)

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Herpes zoster can be identified by a typical:


A) unilateral rash and pain along a cranial nerve or dermatome.
B) weakness and muscle atrophy in the legs.
C) ascending paralysis commencing in the legs.
D) skeletal muscle spasms in the face and neck.

E) C) and D)
F) A) and B)

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The primary reason for seizures frequently occurring with head injuries is:


A) presence of blood irritates the neurons.
B) otorrhea or rhinorrhea changes intracranial pressure.
C) inflammatory response causes general hypoxia.
D) CNS is depressed.

E) B) and D)
F) A) and B)

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Secondary brain tumors usually arise from:


A) severe head trauma.
B) metastasized breast or lung tumors.
C) exposure to carcinogenic agents.
D) exposure to radiation.

E) All of the above
F) B) and C)

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